Study on the Association Between Serum Vitamin D Levels and the Risk of Osteoporosis
血清维生素D水平与骨质疏松风险的关联研究

摘要

血清25-羟维生素D是评价维生素D营养状态的主要指标，其不足可通过降低钙吸收、诱发继发性甲 状旁腺功能亢进及削弱肌力等途径影响骨骼健康。现有观察性研究显示，低水平25-羟维生素D与骨密度下 降及髋部骨折风险增加相关，但该关联受到年龄、季节、肥胖、慢性疾病和活动能力等因素影响。维生素D 检测可用于骨质疏松综合风险评估，但不能单独诊断骨质疏松；补充干预应面向缺乏者，并与钙营养、抗骨 质疏松治疗和防跌倒措施结合。

Abstract

Serum 25-hydroxyvitamin D is the primary indicator used to assess vitamin D status. Vitamin D insufficiency may adversely affect skeletal health by reducing calcium absorption, inducing secondary hyperparathyroidism, and weakening muscle strength. Existing observational studies indicate that low serum 25-hydroxyvitamin D levels are associated with decreased bone mineral density and an increased risk of hip fracture, although this association may be influenced by factors such as age, season, obesity, chronic diseases, and physical mobility. Vitamin D testing can be incorporated into a comprehensive assessment of osteoporosis risk but should not be used alone to diagnose osteoporosis. Vitamin D supplementation should primarily target individuals with deficiency and should be combined with adequate calcium intake, anti-osteoporosis therapy, and fall-prevention measures.